In Vivo Scientist with entrepreneurial ambitions
Do you thrive in a fast-paced, innovative environment where cutting-edge research translates into impactful new therapies? Are you a highly skilled in vivo immunologist eager to lead pre-clinical testing and contribute to the launch of a new company? Then join us at The BioInnovation Institute (BII) at Nørrebro, where we are currently looking for an experienced In Vivo Scientist / Immunologist to play a key role in our company-creation program.
The mission of BII is to create new life science solutions to address unmet societal or health needs. At BII, we have established a program, Bio Studio, which aims to build life science start-ups based on world-class research. Bio Studio projects are three-year grant funded projects sourced from leading researchers employed at research institutions worldwide. The projects we admit combine scientific novelty, commercial viability, and the potential for significant societal and/or health impact. The goal of the projects is to create a viable start-up company based on the project within the three years.
BII aims to recruit a strong project team for each Bio Studio project, and it is expected that this team will form the core of the future start-up deriving from the project. Apart from establishing a solid Project Team, to be headed up by an Entrepreneur in Residence, BII provides a comprehensive network of industry, investors, and subject matter experts to support the projects.
Your Opportunity to Join BII’s Bio Studio Program!
We are launching an exciting new project focused on developing cutting-edge in-vivo drug delivery technology with specific applications in targeted gene delivery for oncology treatments. This innovative project has been initiated by highly renowned Principal Investigators from a leading Danish research organization and represents a significant opportunity to advance therapeutic approaches in cancer treatment.
As part of BII's Bio Studio program, this project aims to transform groundbreaking research into a viable startup company within a three-year timeframe. You will have the unique opportunity to work at the forefront of nanomedicine, collaborating with world-class scientists to develop polymeric nanoparticle technologies that could revolutionize how genetic material is delivered to target cells in cancer patients.
By joining our team, you will play an instrumental role in bringing this promising technology from laboratory concept to clinical application, with the potential to significantly impact cancer treatment paradigms and patient outcomes. You will drive the pre-clinical evaluation of our novel polymer-based nanoparticles, conducting both in vivo and in vitro studies (wet lab work) to thoroughly assess their efficacy and safety in immune cell delivery. Beyond experimental work, you will be instrumental in bridging preclinical findings to clinical applications and contributing to the regulatory process by meticulously documenting immunological data and toxicity assessments. Importantly, you will also oversee external collaborations for in-vivo studies, coordinating activities at facilities with animal research capabilities that are not part of BII. Hence, part of the time will be spend at another facility, and the ability to work at different facility in Copenhagen is needed.
Your ownership of our mutual journey will be to:
- Design and execute in-vivo and in-vitro studies to assess the efficacy and safety of polymer-based nanoparticles for immune cell transfection.
- Develop and optimize preclinical models for cancer immunotherapy, with a present focus on T cell-based therapeutics.
- Perform advanced immunological assays (e.g., flow cytometry, ELISA, cytokine profiling, and functional assays) to evaluate immune responses and transfection efficiency.
- Lead toxicity studies to assess nanoparticle biocompatibility and immunogenicity in relevant animal models.
- Establish and implement protocols for immune cell isolation, culture, and gene transfection.
- Collaborate with cross-functional teams, including chemists and molecular biologists, to refine nanoparticle formulations for improved delivery.
- Analyze and interpret experimental data, generating insights to guide nanoparticle optimization and therapeutic development.
- Support regulatory compliance efforts by documenting study findings and contributing to preclinical safety assessments.
- Oversee external collaborations for in-vivo studies, including work at facilities with animal research capabilities. Hence, flexibility to work at another location than BII.
Your daily work and well-being will be shared directly with the Entrepreneur in Residence, but as a small community with close ties and bright minds, you should be prepared for many cross-functional and inspiring discussions that can help shape your work at BII.
Your Professional & Personal Qualifications
We're looking for a creative problem-solver who's passionate about developing innovative nanoparticle technologies. You thrive at the intersection of chemistry and biology, combining technical expertise with genuine curiosity. Proficiency in English (written and spoken) is essential, along with extensive experience in experimental design and execution, including in vivo studies. You're adept at using project planning software and employing sound project management methodologies to consistently meet deadlines and maintain high-quality work. Most importantly, you bring enthusiasm and a growth mindset to build something meaningful.
Besides this, you have:
- Ph.D. in Immunology, Life Sciences, Cell Biology, or a related field with a focus on immune cell function and therapeutic applications.
- Strong background in in-vivo and in-vitro immunology, particularly in immune cell transfection and gene delivery.
- Experience with preclinical models for cancer immunotherapy, including T cell-based therapies.
- Proficiency in cell culture techniques, immune cell isolation, and gene modification methods.
- Hands-on expertise with immunological assays such as flow cytometry, ELISA, cytokine profiling, and single-cell analysis.
- Familiarity with nanoparticle-based drug delivery systems and their interactions with immune cells.
- Knowledge of toxicology and safety assessment in preclinical models.
Preferred Experience:
- Hands-on experience with in-vivo and in-vitro models for immune-oncology and autoimmune diseases.
- Expertise in high-dimensional immunological analysis, including flow cytometry, single-cell sequencing, and cytokine profiling.
- Experience working in an industrial setting, particularly in gene therapy, mRNA delivery, or nanomedicine
- Ability to communicate complex scientific concepts clearly, including presenting to stakeholders.
You are intensely curious about the relevant concepts in cancer biology, passionate about developing your skills and expertise, and you thrive working both independently and collaboratively in a fast-paced research environment.
Your Experience Working at BII
We offer a committed and professional workplace in which we emphasize ensuring that our colleagues thrive, are challenged, and have opportunities to develop their potential. A career at BII allows you to work with world-leading entrepreneurial scientists in a position where you will have a substantial chance to impact your job and the opportunity to develop your bio entrepreneurial skills.
BII invites you to become part of a vibrant and professional workplace with a chance to bring ideas to life and science to market for the benefit of society and human welfare.
Are you curious for more?
For more information, don't hesitate to contact Kåre Engkilde, Entrepreneur in Residence, via e-mail: ken@biostudio.dk or on the phone: +45 51840577. The deadline for applying for this job is 13/04/2025. However, we will hold interviews on a rolling basis and encourage you to send your application as soon as possible.
To apply, please submit your CV and cover letter by clicking on the “Apply now” button.
