Company Description

ExpreS2ion Biotechnologies is a clinical-stage biotech firm in Hørsholm, focused on developing new vaccines and immunotherapy products. Its discovery platform, ExpreS2, enables rapid and efficient production of complex proteins for vaccines, immunotherapy, and diagnostics. The COVID-19 vaccine (ABNCoV2) validated the ExpreS2 platform for clinical phase III use, utilizing virus-like particle (VLP) technology to enhance immunogenicity. The pipeline also includes a proprietary HER2-cVLP vaccine for breast cancer, using the same VLP approach. ExpreS2ion's innovative platforms have fostered successful collaborations within the biotech and pharma industries.

Role Description

This is a full-time on-site role for a Laboratory Technician at ExpreS2ion Biotechnologies in Hørsholm. The Laboratory Technician will be responsible for conducting quality control tests, utilizing analytical skills, operating laboratory equipment, and performing various laboratory tasks to support research and development projects.

In a modest size company we all help each other and your tasks may vary from week to week, but your focus will be on supporting the downstream department primarily with QC analysis and also other tasks within the general field of protein production, including:

Support for development and production processes as well as process documentation (buffer preparation, DNA preparation, various analyses, documentation)
Protein purification with column chromatography at lab scale.
Managing project workflow to ensure on-time delivery: from initial planning, experiment execution to critical assessment of the data you generate.

Qualifications

You have at least 2 years of experience in research and development in industrial or academic settings and have proven the ability to properly document the work performed.

Experience working as a Laboratory Technician
Experience with analysis of proteins
Quality Control and Analytical Skills
Strong attention to detail and organizational skills
Laboratory Equipment and Laboratory Skills proficiency
Ability to follow strict laboratory safety protocols and procedures
Knowledge of Good Laboratory Practices (GLP) is a plus
Proficiency in English is a requirement

You must have (or be willing to acquire):

in-depth knowledge of column chromatography (e.g. ion exchange, hydrophobic interaction, affinity and preparative gel filtration).
Knowledge of Äkta chromatography systems and programming of Unicorn software.
Knowledge of tangential flow filtration and other protein filtration techniques.
Broad experience with various protein analysis techniques (such as Bradford, BCA, SDS-PAGE, HPLC-SEC, Immunoblotting, ELISA, DLS, CE, AUC).
Practical experience with DNA cloning, analysis and preparation (agarose gel electrophoresis, restriction analysis, PCR)
Grow E. coli cultures in shake flask or fermentation. Harvest and homogenize E. coli cultures.

The team:

You will become a member of the ExpreS2ion team in DTU Science Park in Hørsholm where we are 18 dedicated colleagues ready to welcome you. If there are any specific techniques you lack experience with, we have a team of researchers ready to train you in them. The most important thing is that you are ready to acquire new knowledge.

The entrepreneurial spirit is very much a part of our culture. While we work seriously and result-oriented to achieve our ambitions to grow, we also insist on maintaining a good team culture, developing together, helping each other and learning new things. We are a team of both foreign and Danish colleagues, hence the company language is English.

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