Director, Radiochemistry
Are you ready to uplevel your career? Join an innovative biopharmaceutical company and be part of our exciting journey!
We are looking for a Director, Radiochemistry to join our team.
Working with Us
At Y-mAbs Therapeutics (NASDAQ: YMAB), our mission is to become the world leader in developing better and safer radioimmunotherapy and antibody-based oncology products addressing clear unmet pediatric and adult medical needs. With the right partnerships and collaborations, we envision changing the course of cancer treatment and improving outcomes for patients and their families.
We have offices in Princeton, New Jersey (US) and Hørsholm, Denmark (near Copenhagen). We also have a laboratory based in Nutley, New Jersey (US).
Y-mAbs has an exciting future ahead. If you are passionate about being part of a truly patient-centric organization focused on developing and commercializing cutting-edge therapies to treat a variety of cancers, we want to hear from you!
About the Role
The Director, Radiochemistry position combines deep scientific expertise with strategic project oversight, regulatory input, and cross-functional leadership to drive our radiopharmaceutical pipeline from discovery through clinical readiness using a fit-for-purpose approach. This role will work with other CMC team members, as well as cross-functional team members (Clinical, Nonclinical, Regulatory Affairs, Quality Assurance) and is responsible for overseeing all aspects of radiochemistry development, including research on current and new synthesis methods, nonclinical (early stage, small scale manufacturing), and GMP production in accordance with applicable regulations and QA standards for clinical use. This position will manage vendors, budgets, and resources, while also ensuring the development and execution of strategic research initiatives in radiochemistry for Y-mAbs. The Director, Radiochemistry will work within a regulatory and quality-focused organization and is expected to oversee the development of novel radiopharmaceuticals (diagnostics and therapeutics), including the design, synthesis, automation, purification, quality control, and optimization of chat small molecules and biologics labeled with positron, β-, γ-, and α-particle emitters with a focus on translation from research to clinical use.
Key Responsibilities
- Radiochemistry Strategy & Scientific Leadership: Design and implement state-of-the-art radiochemical solutions to enable both diagnostic and therapeutic programs. Lead the synthesis, radiolabeling, and optimization of small molecules, peptides, and other radiopharmaceutical constructs. Develop and refine radiochemistry- and radiobiology-based assays that accelerate discovery timelines and data quality. Act as a subject matter expert (SME) in radiochemistry within the organization, providing strategic and technical leadership across teams. Stay current with emerging trends in radiopharmaceuticals to introduce innovative approaches and technologies.
- Cross-Functional and External Collaboration: Collaborate closely with other CMC (non-radiochemistry) team members, Clinical, Nonclinical, Regulatory, and Quality teams to integrate radiochemistry across functional pipelines. Build and maintain effective relationships with vendors and academic/industry partners to support pipeline progress. Contribute to strategic intellectual property filings by working with the IP team to identify and protect innovations. As applicable, recruit, mentor, and lead a high-performing team of radiochemists, fostering innovation and scientific rigor.
- Project Management: Serve as the radiochemistry SME within CMC development projects, guiding strategy from early-stage to regulatory filing. Manage multiple projects from concept through preclinical stages, ensuring delivery against milestones, timelines, and corporate goals. Efficiently allocate internal and external resources, including budget oversight, to meet operational objectives. Develop and manage comprehensive project plans, coordinating with internal stakeholders and external vendors to ensure timely delivery. Provide key input into regulatory documentation (e.g., pre-IND, IND) specific to radiochemistry and CMC components. Support the preparation and validation of clinical trial materials in line with filing strategies. Oversee initiation of change controls, review of deviations, and quality investigations from CMOs and logistics partners. Participate in all regulatory and quality requirement activities (e.g., annual reports, audits, etc.).
- Radiation Safety Officer: Serve as the Company’s RSO and support all activities (reporting, training, etc.) related to radiation safety.
- Continuous Improvement and Best Practices: Contribute to the development and implementation of best practices.
- Quality Assurance and Regulatory Affairs: Ensure all studies adhere to applicable regulations (e.g., 21 CFR 210, 211, 212).
Key Qualifications
- Education & Experience: PhD in Radiochemistry, Inorganic Chemistry, Organic Chemistry, or related field. Minimum of 8 years of experience working in radiochemistry/radiopharmaceutical development and scale-up required; a mixture of academic (leadership role) and industry accepted. At least 5 years working with products for clinical use required (e.g., GMP or country equivalent). A minimum of 2 years in leadership role. Diagnostic and therapeutic radiopharmaceutical expertise required, including a proven history of advancing compounds from discovery through clinical development.
- Skills: Hands on experience with imaging radioisotopes and therapeutic radioisotopes. Experience in quality control testing of radiolabeled compounds. Proficient in MS Office (Excel, Word, PowerPoint, Teams). Excellent written communication (posters, presentations, study reports, scientific communications, etc.). Experience with environmental health and radioprotection requirements. Working knowledge of multiple automated radiosynthesizers. Knowledge of industry players in automation, infrastructure, and supply chain. Proficient in GMP and applicable FDA , EMA, USP, and ICH guidelines.
- Attributes: High degree of initiative, agility, proactivity, and flexibility to adjust to evolving Company needs. The ability to thrive in an organization that values innovation, adaptability, and a commitment to delivering meaningful results for patients.
- Desired Characteristics: Ability to handle ambitious timelines and work effectively with cross-functional teams.Experience working with radiopharmaceutical clinical trials is a plus.Knowledge of industry trends and methodologies.
- Travel: Up to 30%.
Location
This role is based in our Princeton Office with a hybrid working pattern.
Compensation
The salary range for this role is $175,000 - $225,000 plus an annual discretionary bonus. The actual salary will vary based on applicant`s experience, certifications, education, etc, as well as local compensation benchmarks. This position also will be provided with the opportunity to enroll in Medical, Dental, Vision, Short-term Disability and Long-term Disability insurance coverage plans which the Company pay 100% of the premiums. Y-mAbs also provides competitive PTO and Sickness leave benefits.
Interested in Applying
If you are interested in joining Y-mAbs and becoming part of our team in a fast-moving environment that offers a unique combination of scientific insight, entrepreneurship, and exciting challenges, please apply!
Equal Employment Opportunity Statement
It is the policy of Y-mAbs to provide employment, training, compensation, promotion and other conditions of employment without regard to a person’s sex/gender, pregnancy (including childbirth, breastfeeding and related medical conditions), age, race, color, religion, creed, sexual orientation, gender identity, gender expression, genetic information, marital status, familial status, civil union or domestic partner status, nationality or national origin, ancestry, citizenship, immigrant status, military status, veteran status, handicap, physical or mental disability, use of a trained service animal, medical condition, atypical hereditary cellular or blood trait, victim of domestic violence crime, sexual assault or stalking or membership in any “protected group” under federal, state or local law. This policy applies to all conditions of employment including but not limited to recruitment, selection, placement, transfer, promotion, training, compensation, benefits and termination.
All decisions regarding conditions of employment must and will be based on the individual's overall qualifications and their ability to meet the requirements of the position. Applicants and employees with disabilities will be provided with reasonable accommodations, except where such accommodation would cause Y-mAbs undue hardship. If you need assistance and/or a reasonable accommodation due to a disability during the application or recruiting process, please contact Chris Naylor at cna@ymabs.com. Y-mAbs will use its utmost discretion in keeping such information confidential and shall disseminate such information only on a “need to know” basis only.
